Blar i forfatter "Brox, Jan"

Viser treff 1-20 av 21

    • The Association Between Self-Reported Symptoms of Recent Airway Infection and CRP Values in a General Population 

      Melbye, Hasse; Amundsen, Kristine; Brox, Jan; Eggen, Anne Elise (Journal article; Tidsskriftartikkel; Peer reviewed, 2011-11-17)
      C-reactive protein (CRP) is a much used biomarker for respiratory tract infection; however, the influence of airway infection on the CRP level in the general population has not been well described. The study aimed to evaluate the impact of recent symptoms of airway infection on the CRP level and how the predictive power of other known CRP predictors is influenced by taking respiratory symptoms ...

    • Bør vi spise mer fisk – eller mindre? 

      Bolann, Bjørn; Huber, Sandra; Averina, Maria; Eggesbø, Merete Åse; Hokstad, Ingrid; Brox, Jan; Ørebech, Peter Th; Monsen, Anne-Lise Bjørke (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)

    • C-reactive protein and risk of venous thromboembolism: Results from a population-based case-crossover study 

      Grimnes, Gro; Isaksen, Trond; Tichelaar, Ynse Ieuwe Gerardus Vladimir; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-04-19)
      Long-term, low-grade inflammation does not seem to be a risk factor for venous thromboembolism. The impact of acute inflammation, regardless of cause, on risk of venous thromboembolism is scarcely studied. We aimed to investigate the impact of acute inflammation, assessed by C-reactive protein, on short-term risk of venous thromboembolism. We conducted a case-crossover study of patients with venous ...

    • Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function - the Tromso study 

      Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Vik, Anders; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      Background Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study. Design and ...

    • Early menarche and other endocrine disrupting effects of per- and polyfluoroalkyl substances (PFAS) in adolescents from Northern Norway. The Fit Futures study 

      Averina, Maria; Huber, Sandra; Almås, Bjørg; Brox, Jan; Jacobsen, Bjarne K.; Furberg, Anne-Sofie; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-19)
      Background: Per- and polyfluoroalkyl substances (PFAS) comprise a large group of chemicals that are ubiquitous in the environment and include recognized persistent organic pollutants. The aim of this cross-sectional study was to investigate possible endocrine disrupting effects of different PFAS in adolescents. <p> <p>Methods: Serum concentrations of PFAS, thyroid, parathyroid and steroid hormones ...

    • Exposure to perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in adolescents : the Fit Futures study 

      Averina, Maria; Brox, Jan; Huber, Sandra; Furberg, Anne-Sofie (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-15)
      Background - Prevalence of obesity, hypertension and dyslipidemia has been increasing in children and adolescents worldwide. Exposure to environmental pollutants may contribute to this development. Our aim was to study associations between perfluoroalkyl substances (PFAS) and dyslipidemia, hypertension and obesity in a population-based sample of adolescents. <p> <p>Methods - Serum PFAS concentrations ...

    • High-sensitivity C-reactive protein is not a risk factor for venous thromboembolism: the Tromso study 

      Hald, Erin Mathiesen; Brækkan, Sigrid Kufaas; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      High-sensitivity C-reactive protein is associated with risk of arterial cardiovascular disease but conflicting results have been reported on its role in venous thromboembolic disease. The objective of our study was to investigate the association between high-sensitivity C-reactive protein levels and risk of future venous thromboembolism in a prospective cohort recruited from a general population. ...

    • Human articular chondrocytes express ChemR23 and chemerin; ChemR23 promotes inflammatory signalling upon binding the ligand chemerin 21-157 

      Berg, Vivian; Sveinbjørnsson, Baldur; Bendiksen, Signy; Brox, Jan; Meknas, Khaled; Figenschau, Yngve (Journal article; Tidsskriftartikkel; Peer reviewed, 2010)
      Chemerin is a chemotactic peptide which directs leukocytes expressing the chemokine-like receptor ChemR23 towards sites of inflammation. ChemR23 is a G protein-coupled receptor which binds several different ligands, and it is also expressed by other cell types such as adipocytes. In addition to chemotaxis, recent reports suggest that ChemR23 is capable of mediating either inflammatory or anti-inflammatory ...

    • Høyt nivå av tungmetaller i krabbe 

      Averina, Maria; Monsen, Anne-Lise Bjørke; Bolann, Bjørn Johan; Brox, Jan; Eggesbø, Merete; Hokstad, Ingrid; Huber, Sandra; Ørebech, Peter Th (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-01)
      Krabber er populær sjømat, men kan inneholde til dels store mengder miljøgifter. Innholdet er mange steder i Norge så høyt at inntak av brunmaten generelt bør frarådes.

    • Impaired gross motor development in infants with higher PFAS concentrations 

      Varsi, Kristin; Huber, Sandra; Averina, Maria; Brox, Jan; Monsen, Anne-Lise Bjørke; Torsvik, Ingrid Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-17)
      Industrial produced perfluoroalkyl substances (PFAS) are environmentally persistent and found in humans around the globe. PFAS is transferred from mother to child during pregnancy and lactation and PFAS concentrations are high in infants. PFAS exposure in early life has been linked to a range of negative health effects. In the present study we have investigated PFAS concentrations in mothers (pregnancy ...

    • Investigation of background contribution from different solvent brands used for sample preparation and analysis of persistent organic pollutants 

      Götsch, Arntraut; Averina, Maria; Brox, Jan; Huber, Sandra (Journal article; Tidsskriftartikkel; Peer reviewed, 2023)
      In the times of pandemic, we experienced problems with supply bottlenecks for the solvents normally used for extraction and analysis of persistent organic pollutants (POPs; i.e. PCBs, PBDEs and organochlorine pesticides) in our laboratory and, considered to start using solvents from another producer alternatively. Since we analyze POPs at very low concentration levels and other consumables are ...

    • NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population 

      Averina, Maria; Stylidis, Michael; Brox, Jan; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-23)
      Aims The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population.<p> <p>Methods and results Altogether, 1936 participants were randomly selected ...

    • Perfluoroalkyl substances (PFASs) and mercury in never-pregnant women of fertile age: association with fish consumption and unfavorable lipid profile 

      Monsen, Anne Lise Bjørke; Varsi, Kristin; Averina, Maria; Brox, Jan; Huber, Sandra (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-04)
      <p><i>Objectives</i> - To examine concentrations of perfluoroalkyl substances (PFASs) and lifestyle factors that may contribute to higher levels of pollutants in never-pregnant women of fertile age.<p> <p><i>Design</i> - Observational cross-sectional study.<p> <p><i>Setting</i> - Participants were recruited among employees and students at Haukeland University Hospital and the University of ...

    • Quantitation of linear and branched perfluoroalkane sulfonic acids (PFSAs) in women and infants during pregnancy and lactation 

      Varsi, Kristin; Huber, Sandra; Averina, Maria; Brox, Jan; Monsen, Anne-Lise Bjørke (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-24)
      Background: Per- and polyfluoroalkyl substances (PFAS) are associated with negative health effects, and exposure during fetal life and infancy are of concern. A subgroup of PFAS, linear and branched perfluoroalkane sulfonic acids (PFSA), have significant differences in biochemical reactions, bioaccumulation and potential toxic exposure effects, and data on transfer of PFSA isomers from mother to ...

    • Red cell distribution width and carotid atherosclerosis progression: The Tromsø study 

      Lappegård, Jostein; Ellingsen, Trygve; Vik, Anders; Skjelbakken, Tove; Brox, Jan; Mathiesen, Ellisiv B.; Johnsen, Stein Harald; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-29)
      Red cell distribution width (RDW), a measure of the size variability of circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with progression of atherosclerotic plaques in subjects recruited from the general population. Baseline characteristics, including RDW, were collected from 4677 participants in the fourth survey ...

    • Red cell distribution width is associated with future risk of incident stroke. The Tromsø study 

      Lappegård, Jostein; Ellingsen, Trygve; Skjelbakken, Tove; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brox, Jan; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-20)
      Red cell distribution width (RDW), a measure of the variability in size of the circulating erythrocytes, is associated with cardiovascular morbidity and mortality. We aimed to investigate whether RDW was associated with incident stroke and case fatality in subjects recruited from the general population. Baseline characteristics were obtained from 25,992 subjects participating in the fourth ...

    • Red Cell Distribution Width Is Associated With Incident Myocardial Infarction in a General Population: The Tromsø Study 

      Skjelbakken, Tove; Lappegård, Jostein; Ellingsen, Trygve; Barrett-Connor, Elizabeth; Brox, Jan; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Serum osteoprotegerin and future risk of cancer and cancer-related mortality in the general population: the Tromsø study 

      Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Serum osteoprotegerin and renal function in the general population: The Tromsø Study 

      Vik, Anders; Brodin, Ellen Elisabeth; Mathiesen, Ellisiv B.; Brox, Jan; Jørgensen, Lone; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-10-03)
      <p><i>Background</i>: Serum osteoprotegerin (OPG) is elevated in patients with chronic kidney disease (CKD) and increases with decreasing renal function. However, there are limited data regarding the association between OPG and renal function in the general population. The aim of the present study was to explore the relation between serum OPG and renal function in subjects recruited from the general ...

    • Serum osteoprotegerin levels are related to height loss : the Tromsø Study 

      Jørgensen, Lone; Hansen, John-Bjarne; Brox, Jan; Mathiesen, Ellisiv B.; Vik, Anders; Jacobsen, Bjarne Koster (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Severe loss of body height is often a consequence of osteoporotic vertebral fractures. Osteoprotegerin (OPG) and receptor activator of nuclear factor-kB ligand (RANKL) are cytokines essential for the regulation of bone resorption. The aim of this study was to assess the relationship between the OPG/RANKL system and height loss. A total of 4,435 inhabitants from the municipality of Tromsø, ...